Recombinant AAV mediated genome engineering

Recombinant AAV mediated genome engineering

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  • GENESIS™ Precision Genome Editing with CRISPR and rAAV

    YouTube 02:46
  • Canine Studies of AAV Mediated Gene Transfer

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  • rAAV Genome Editing - Horizon Discovery

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  • How AAV Gene Transfer Works - General Audience

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  • DNA - Kendrick Lamar (AUDIO)

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  • The Nobel Prize – explained in a nutshell

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  • International Standard Book Number (ISBN)

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  • Genome Editing with engineered nucleases

    YouTube 02:17
  • Recombinant DNA Technology

    YouTube 03:53
  • SNPs (Single Nucleotide Polymorphism)0 (Better Explained)

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  • Transformation, Conjugation, Transposition and Transduction

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  • Double strand break repair | homologous recombination

    YouTube 02:32

Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of rAAV vectors that enables insertion, deletion or substitiution of DNA sequences into the genomes of live mammalian cells. The technique builds on Capecchi and Smithies' Nobel Prize–winning discovery that homologous recombination (HR), a natural hi-fidelity DNA repair mechanism, can be harnessed to perform precise genome alterations in mice. rAAV mediated genome-editing improves the efficiency of this technique to permit genome engineering in any pre-established and differentiated human cell line, which, in contrast to mouse ES cells, have low rates of HR.

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