Tanglewood Plantation, also known as the Ellison Durant Smith House, is a historic plantation house located at Lynchburg, Lee County, South Carolina. It was built about 1850, and is a two-story, Greek Revival style clapboard house. It features a two-story pedimented front portico supported by four square columns on freestanding brick piers. A two-story projecting wing was added to the west façade in 1915, as well as a kitchen ell alteration to the south (rear) façade. Outbuildings include a pine clapboard kitchen building, a round-cut log constructed smokehouse, and a one-room schoolhouse. Tanglewood was the home of Ellison Durant "Cotton Ed" Smith, United States Senator from 1908 to 1944, and Alexander Coke Smith, Bishop of the Methodist Conference from 1902 until 1906.