Cincinnati is a city in the U.S. state of Ohio and is the government seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers. The city drives the Cincinnati–Middletown–Wilmington combined statistical area, which had a population of 2,172,191 in the 2010 census. With a population of 301,301, Cincinnati is the third-largest city in Ohio and 65th in the United States. It is the fastest growing economic power in the Midwestern United States based on percentages and the 28th-biggest metropolitan statistical area in the U.S. Cincinnati is also within a single day's drive of two-thirds of the United States populace.